Projections: reviews and commentary

Projections is a work of literary nonfiction, telling a story in which the protagonist is the human mind.

Each individual thread in Projections arises from the author’s emergency-room experience as a psychiatrist—with the language in every story adapted to evoke inner states unique to the disorder: the exuberance of mania, the weight of grief, the fragmentation of psychosis.

At the heart of Projections are these experiences of individuals in altered mental states—each in a moment of intense crisis—but every experience is entwined with the larger story of the human family: across the globe, spanning evolutionary time, and enfolding ideas from literature, modern neuroscience, and imagination.

Critically acclaimed around the world, both by literary reviewers and in the scientific community, Projections is an internationally published bestseller with editions in more than 15 languages.

Projections by Karl Deisseroth — book cover

Reviews

“Karl Deisseroth is already known around the world as a groundbreaking scientist who has pioneered dazzling new techniques for investigating the brain. In this enthralling masterpiece of a book, he demonstrates that he is also a perceptive psychiatrist, as well as a spellbinding writer who beautifully connects the inner feelings within all human beings to deep insights from modern psychiatry and neuroscience.”

Robert Lefkowitz

Nobel Laureate and author of A Funny Thing Happened on the Way to Stockholm

Projections asks probing questions about some of our most fundamental human traits, to shed light on the origins of our emotions. Deisseroth writes of heartbreaking and desperate medical cases with a doctor’s knowledge, and a novelist’s skill for narrative. I could not put this book down.”

May-Britt Moser

Nobel Laureate

“a stunning work … [Deisseroth] produces Joycean flights of language … [T]he bedrock of his work is the personal encounter, with all its messy cultural baggage, but he has the imagination and literary gift to make it speak to all of us.”

Literary Review

“A book that is beautiful to read….”

The Observer

“Sets itself apart with Deisseroth’s lyrical writing and the empathy of his storytelling.”

Library Journal

Starred review

“Karl Deisseroth is a Master Storyteller. Armed with an abundance of compassion and curiosity, he takes us on a spellbinding tour of the mysteries of the human mind through a series of fascinating case studies. His graceful prose weaves a tapestry of complex ideas into memorable stories, each illuminated by cutting-edge science. A delight from the opening paragraph to the stunning conclusion, this book is an invitation to reverence for the complexity of the human brain and its relationship to the mind: a ticket to a state of wonder at the essence of ourselves.”

Kathryn Mannix

Author of With the End in Mind

“I find myself at a loss for how to describe this remarkable work. Just as Karl has, through his laboratory, reimagined, and literally redefined how we view the human brain, he has reimagined and redefined what literary non-fiction can be, with great elegance. For all of us who write about science for the public, this will be a tough act to follow. It’s poetic, mind-stretching, and through it all, deeply human. I am driven to the brink of despair: whether to chuck my writing career altogether, or double down, and work like a madman to try and write something half this good.”

Dan Levitin

New York Times-bestselling author of The Organized Mind

“Karl Deisseroth intertwines neuroscience and human stories in a way that is altogether new: technical, lyrical, and deeply compassionate all at once. Through sharing what he’s learned as a groundbreaking scientist and a psychiatrist caring for patients with severe illness, he reveals a glimmer of what makes us human. This is a crucial book for anyone who loves science, anyone who loves someone suffering from a disorder of the brain, or anyone who, like so many of us, loves both.”

Lucy Kalanithi

“In this magisterial work, Karl Deisseroth shows that he is not only one of our leading scientists, he is also a gifted writer and storyteller. With precise, yet luminous prose, he merges stories of cutting-edge neuroscience with a deep reverence for his patients’ humanity.”

Neil Shubin

Author of Some Assembly Required

“Unique and utterly riveting, Projections braids together three skeins from Karl Deisseroth’s life: his painstaking clinical experience as a psychiatrist, dedicated to helping patients; his ingenious inventions in biotechnology; and his life as a humble and caring social human being with a gift for crafting a spellbinding chronicle. This is a masterpiece written for each and every one of us.”

Patricia Churchland

Author of Conscience

“I’ve known Karl as a colleague, a scientist whose discoveries in the lab have been breathtaking and revolutionary. Maybe I shouldn’t be surprised to discover he’s also a stunning writer, his words guiding us to a profound understanding of the nature of human emotions, seamlessly invoking Ovid and optogenetics, Borges and basal ganglia as he takes on this journey. Projections is a tour de force.”

Abraham Verghese

Author of Cutting for Stone

Literary blog and updates

More good conversation, with Lex Fridman

A thoughtful conversation with Lex Fridman… spanning so much, beginning with the book, but also bridging neuroscience, psychiatry, literature, cinema, Borges, the Brothers Karamazov, Finnegans Wake… and of course human emotion and connection.

Toward the end we touch on the much-discussed Gedankenexperiment that also closes Projections, as published last year.

The whole episode is clickable, but you can jump right to the thought experiment here if the preceding 3 hours is too much at the moment.

Six months in…

Reflecting on the half-year milestone, since the early days of our June publication.

As a humble scientist, who just likes words, I feel incredibly fortunate to have written and shared a literary adventure like Projections, especially since it is so far from being a traditional scientific text.

The positivity from literary critics and biologists alike has been amazing, and via the international editions, to make contact with so many cultures and languages around the world, just by writing, is simply a dream come true.

The Lasker Public Lecture

One reason to be a little preoccupied — in September the Lasker Award for Basic Medical Research was awarded to my friends and colleagues Peter Hegemann and Dieter Oesterhelt, along with me, for our discoveries on microbial opsins, which are fundamental tools for optogenetics but also pretty cool little bio-devices from nature that turn light into electricity.

This resulted in the 2021 Lasker Public Lecture. The lecture was designed for everyone, as well as for scientists, and it’s just a moment in time of sharing the joy: basic science discovery, through curiosity-driven exploration of the natural world.

The image was sent from Berlin by Peter Hegemann: the Lasker emblem, the winged Nike, or victory, of Samothrace.

The Lasker emblem: the winged Nike of Samothrace, lit in blue

Book clubs with the community

Great book club at Northwestern with Drs. Talia Lerner, Herbert Meltzer and Sachin Patel (new chair of psychiatry),

Post on X by Sachin Patel: “Outstanding book club today with @KarlDeisseroth hosted by @TaliaLerner at @NUFeinbergMed Inspirational to hear the genesis of “Projections” and discuss the fantastic potential enabled by the quintessential blending of clinical psychiatry and neuroscience.— Sachin Patel (@SachinPatelLab) December 2, 2021”View the post on X

following a wonderful event at Mount Sinai with eminent psychiatrist and neuroscientist Eric Nestler and colleagues.

Post on X by Friedman Brain Institute: “HAPPENING TODAY at 3PM! Join @EricJNestler & @PaulJK27 as they discuss @KarlDeisseroth's recent book "Projections". REGISTER NOW👉🏼https://t.co/dQpJE0m9AU#optogenetics #Clarity #fiberphotometry @LaskerFDN @Stanford @StanfordBrain https://t.co/z6s9RSNnRM pic.twitter.com/LJF8T83xhk— Friedman Brain Institute (@SinaiBrain) November 16, 2021”View the post on X

And fantastic book clubs in Canada (University of Toronto),

Post on X by Jenn Kao: “Today’s talk hosted @uoftmdphd and moderated by @mathepan and I, once again proved @KarlDeisseroth as a pioneer - this time, in bridging the gap between basic science, psychiatry, and literature. (1/4) pic.twitter.com/8zv5tWkf8d— Jenn Kao (@kao_jenn) November 10, 2021”View the post on X

and England (University College London and the Sainsbury Wellcome Centre).

Post on X by Dr. Chunyu Ann Duan: “Dream come true! Tomorrow @KarlDeisseroth will speak at @SWC_Neuro tea hour about his amazing book #Projections ! 4 pm London time. Don’t miss it! https://t.co/3pwgaP0vjg— Dr. Chunyu Ann Duan (@AnnDuan2) November 25, 2021”View the post on X

More to come soon, in Georgia, Michigan, Minnesota, Texas, New York, and beyond…

Conversation with Alan Alda

A few months in, teaching begins to wind down for fall quarter, and now with the holidays coming I finally have some breathing space, and a chance to reach out to the public and talk about Projections

Post on X by Clear+Vivid: “That's right, it's #ClearAndVivid PODCAST DAY! @alanalda chats with author & neuroscientist, @KarlDeisseroth. With the invention of new ways to explore the brain, he has revolutionized neuroscience. Listen now on your favorite podcast destinations: https://t.co/HbjGpq352z pic.twitter.com/Zza9E4NB3g— Clear+Vivid (@alda) November 2, 2021”View the post on X

Great conversation with Alan Alda on Projections, optogenetics, psychiatry, and more. He’s very well-read, and every bit as much fun as you might think. The conversation wound from science to sprung rhythm; then he sprang seven surprise questions around the 31-minute mark.

The first two weeks

I’ve been so heartened by all the responses to Projections over the first two weeks since launch. As one example, in Science, regarding the “weaving together … psychiatric knowledge, technology, and imagination” in Projections, the review went on to say “These together free him to write poetically…. His narratives are always sensitive … an admixture of fact and fiction, reality and imagination, damage and desire.”

This kind of response from the reading public is so valuable since it can feel awkward, in conveying exciting modern science, to also make clear the limits of knowledge. But it was worth the effort for this book, and the public response shows that readers get it, understanding that many exciting discoveries are still in our future…

Thanks to all readers who are sharing #Projections by word-of-mouth or posting photos and favorite passages, as well as to all the local or indie bookstores. (Menlo Park/Kepler’s shown).

Projections on a bookshop display, beneath a “Big Ideas: new in science, tech and business” sign

Launch week June 2021

Projections launched this week! 20 years in the making. And so many positive responses from readers already — thank you all, for embracing this book.

The photo was sent from a bookstore in Soho. It is strange and amazing for just a humble scientist, used to communicating with a specialized community, to see one’s work out there for the public, for all, to see, and to access. It’s hard to describe the feeling, but it is one of unity, perhaps like introducing two of your closest lifelong friends to each other, who had somehow never met, for the first time.

Projections among the New and Noteworthy Non Fiction at McNally Jackson Independent Booksellers

Origins

“Personal inspiration (like scientific discovery) can come from unexpected directions…”

The Prologue to Projections (a personal origin story of sorts — before getting to the stories that form the heart of each chapter) describes my first real interaction with a patient on the locked psychiatry unit, turning a neurosurgeon-to-be into a psychiatrist.

“These days, I sometimes imagine seeking out that schizoaffective disorder patient, with whom I shared that heart-pounding first awakening, to sit down together for a quiet moment of communion, though it has been a long time. A receptivity to the improbable comes very close to the essence of illness on the schizophrenia spectrum, and so he might not be at all surprised to learn that his crossing of the threshold of the nurses’ station that day could have helped in its own way…”

In retrospect it makes some sense, though it didn’t fully at the time. Now I can see that helping psychiatric patients, and writing these stories, and investigating the brain, can be all somehow the same thing: just trying to get to, and describe, a place deep within all of us — a place that is shared.

Two pages from the Prologue to Projections, including the line “Personal inspiration (like scientific discovery) can come from unexpected directions”

International editions

It’s been interesting to see international titles coming in, since the diverse connotations of Projections, in terms of exposing forms that lie within, don’t easily translate (for example in Dutch, the literal translation to Projecties didn’t carry the same rich associations). I’m grateful to my Dutch colleague and neuroscientist Dr. Annemieke Apergis-Schoute for the insight of “Inzichten.”

Spanish, Turkish, Russian, Portuguese, Japanese, Korean, Chinese, German, etc. translations are coming along… Delighted to see international reactions already from Dr. Sue Black, Dr. Kathryn Mannix, and the Bookseller (and others) (& others: https://publishersweekly.com/978-1-984853-69-1).

Viking, our UK publisher, came back with Connections instead of Projections for the UK edition — and with a cover I like for its own rich connotations and lovely imagery. So, unexpectedly, even translation to English was nontrivial.

The Dutch edition, Inzichten, its cover carrying Edward Hopper’s painting Rooms by the Sea
The full jacket of the UK edition, Connections

Audiobook recording!

Coming off a complex, difficult, and rewarding week: intense psychiatry inpatient-attending duty over the nights, interleaved with mornings of inspired, if somewhat disheveled, recording of the Projections audiobook.

I was a bit embarrassed, but glad, to learn how to pronounce a few words I had read and written many times but only heard in my head before, like “arboreal.” 🙂

It was an honor to work with Natalie Naudus and Karen Chilton, in key roles (thanks to these amazing voice actors for joining such an unusual project for the public!)

Karl Deisseroth recording the Projections audiobook in a studio

Projections launch

Greetings! and welcome to Projections. This blog will have information and updates from the literary side, including publishing, commentary, and reviews. I’ll also repost here relevant social media that initially appeared elsewhere.

I am delighted to announce that Projections can be preordered now. The initial book announcement (below) is from February 24, 2021 on Twitter:

This book has been incubating in many ways for 20 years — I wrote the first chapter during my psychiatry residency, before I started my lab at Stanford.

Projections is unusual, not easily captured in a few characters — except I could begin by saying that universal inner experiences of humanity may sometimes be revealed, in the chaos and tumult of emergency psychiatry.

Caring for those with severe mental illness has been a constant thread in my work, starting with 8 years of dedicated medical training and psychiatry residency, followed by inpatient and outpatient care for the past 17 years at Stanford Medicine. I don’t usually speak or write about it.

Still, scientists and artists alike know that the broken might describe the unbroken — whether in geology or genetics or poetry. And part of Projections is the telling of human stories through the throes of personal, or geopolitical, upheaval. Sometimes both at once.

There is a personal side for me as well, in Projections: moments of terror and grief, which helped set me onto the path leading to where we are now; but some of these experiences are tempered now, with later joys that could not have otherwise come to be.

In each story, threads from literature and imagination, from human history and prehistory, and from modern neuroscience, can all be found interwoven with the connections from psychiatry (which alone, I think, would not be enough to show the full picture).

Projections is written for all, but especially for those who have always wondered about mysteries of the mind (whether working smoothly or somewhat less so), and who think about the hope, and the challenges, that may come with understanding.

Projections is for anyone (non-scientist or scientist, art-lover or artist) pondering those feelings that make us human, broken and unbroken as we all are — as individuals and as humanity — by joy and defeat, peacemaking and violence, parenting and loss. And mental illness.

And so Projections belongs also to all who have suffered from (or borne witness to) major illnesses and disorders of the brain: stroke and dementia, brain tumors, bulimia and anorexia, borderline and antisocial personality, depression and bipolar, schizophrenia and autism.

As a physician treating, and seeking to understand, these conditions, I’m profoundly grateful to my patients for their courage — and to my wonderful family who supported me throughout, to the exceptionally brilliant members of my lab, and to my visionary agent and editor.

Take a look if you like, and share if you wish!

-Karl

The cover of Projections with its publication date, June 15, 2021

Karl Deisseroth

Neuroscientist · Psychiatrist · Author

Resources for exploring some of the underlying science—including breakthroughs in optogenetics—can be found here. For active research developments and academic resources, you are welcome to visit the Deisseroth Lab at Stanford, and follow on Bluesky or X.